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2vzi

From Proteopedia

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Current revision (15:38, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2vzi' size='340' side='right'caption='[[2vzi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2vzi' size='340' side='right'caption='[[2vzi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VZI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vzg|2vzg]], [[2vzd|2vzd]], [[1kl0|1kl0]], [[2vzc|2vzc]], [[1kky|1kky]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PXN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PARVA, MXRA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzi OCA], [https://pdbe.org/2vzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzi RCSB], [https://www.ebi.ac.uk/pdbsum/2vzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vzi OCA], [https://pdbe.org/2vzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vzi RCSB], [https://www.ebi.ac.uk/pdbsum/2vzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vzi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PAXI_HUMAN PAXI_HUMAN]] Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). [[https://www.uniprot.org/uniprot/PARVA_HUMAN PARVA_HUMAN]] Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.<ref>PMID:11331308</ref> <ref>PMID:11134073</ref> <ref>PMID:15284246</ref> <ref>PMID:20393563</ref>
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[https://www.uniprot.org/uniprot/PAXI_HUMAN PAXI_HUMAN] Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Campbell, I D]]
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[[Category: Campbell ID]]
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[[Category: Hoellerer, M K]]
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[[Category: Hoellerer MK]]
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[[Category: Lorenz, S]]
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[[Category: Lorenz S]]
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[[Category: Lowe, E D]]
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[[Category: Lowe ED]]
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[[Category: Noble, M E.M]]
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[[Category: Noble MEM]]
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[[Category: Vakonakis, I]]
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[[Category: Vakonakis I]]
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[[Category: Actin-binding]]
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[[Category: Calponin homology domain]]
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[[Category: Cell adhesion]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Cytoskeleton]]
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[[Category: Ld2 motif]]
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[[Category: Lim domain]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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Current revision

Crystal structure of the C-terminal calponin homology domain of alpha- parvin in complex with paxillin LD4 motif

PDB ID 2vzi

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OCA

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