2wf0

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Current revision (01:28, 21 November 2024) (edit) (undo)
 
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<StructureSection load='2wf0' size='340' side='right'caption='[[2wf0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2wf0' size='340' side='right'caption='[[2wf0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tqf|1tqf]], [[1xn3|1xn3]], [[2vnm|2vnm]], [[1m4h|1m4h]], [[1xn2|1xn2]], [[2fdp|2fdp]], [[2viy|2viy]], [[2vie|2vie]], [[2va6|2va6]], [[2vj6|2vj6]], [[2viz|2viz]], [[2b8l|2b8l]], [[1ym4|1ym4]], [[1sgz|1sgz]], [[2va5|2va5]], [[1ujk|1ujk]], [[2b8v|2b8v]], [[1fkn|1fkn]], [[1xs7|1xs7]], [[2vij|2vij]], [[2va7|2va7]], [[1ym2|1ym2]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnn|2vnn]], [[1py1|1py1]], [[1w50|1w50]], [[1ujj|1ujj]], [[2vj7|2vj7]], [[1w51|1w51]], [[2wf3|2wf3]], [[2wf1|2wf1]], [[2wf4|2wf4]], [[2wez|2wez]], [[2wf2|2wf2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf0 OCA], [https://pdbe.org/2wf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf0 OCA], [https://pdbe.org/2wf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf0 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Memapsin 2]]
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[[Category: Charrier N]]
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[[Category: Brien, A O]]
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[[Category: Clarke B]]
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[[Category: Charrier, N]]
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[[Category: Cutler L]]
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[[Category: Clarke, B]]
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[[Category: Demont E]]
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[[Category: Cutler, L]]
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[[Category: Dingwall C]]
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[[Category: Demont, E]]
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[[Category: Dunsdon R]]
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[[Category: Dingwall, C]]
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[[Category: Hawkins J]]
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[[Category: Dunsdon, R]]
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[[Category: Howes C]]
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[[Category: Hawkins, J]]
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[[Category: Hubbard J]]
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[[Category: Howes, C]]
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[[Category: Hussain I]]
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[[Category: Hubbard, J]]
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[[Category: Maile G]]
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[[Category: Hussain, I]]
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[[Category: Matico R]]
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[[Category: Maile, G]]
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[[Category: Mosley J]]
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[[Category: Matico, R]]
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[[Category: Naylor A]]
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[[Category: Mosley, J]]
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[[Category: O'Brien A]]
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[[Category: Naylor, A]]
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[[Category: Redshaw S]]
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[[Category: Redshaw, S]]
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[[Category: Rowland P]]
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[[Category: Rowland, P]]
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[[Category: Smith KJ]]
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[[Category: Smith, K J]]
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[[Category: Soleil V]]
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[[Category: Soleil, V]]
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[[Category: Sweitzer S]]
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[[Category: Sweitzer, S]]
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[[Category: Theobald P]]
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[[Category: Theobald, P]]
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[[Category: Vesey D]]
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[[Category: Vesey, D]]
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[[Category: Walter DS]]
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[[Category: Walter, D S]]
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[[Category: Wayne G]]
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[[Category: Wayne, G]]
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[[Category: Alternative splicing]]
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[[Category: Asp-2]]
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[[Category: Aspartyl protease]]
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[[Category: Bace-1]]
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[[Category: Beta-secretase]]
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[[Category: Beta-site app cleaving enzyme]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Memapsin-2]]
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[[Category: Membrane]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Transmembrane]]
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[[Category: Zymogen]]
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Current revision

Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide

PDB ID 2wf0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wf0"
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