7m2n
From Proteopedia
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==Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15== | ==Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15== | ||
| - | <StructureSection load='7m2n' size='340' side='right'caption='[[7m2n]]' scene=''> | + | <StructureSection load='7m2n' size='340' side='right'caption='[[7m2n]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M2N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M2N FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m2n OCA], [https://pdbe.org/7m2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m2n RCSB], [https://www.ebi.ac.uk/pdbsum/7m2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m2n ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YOJ:5-[(5-{1-(4-carboxy-1,3-thiazol-2-yl)-5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-3-yl}-2-fluoro[1,1-biphenyl]-4-yl)oxy]-1H-1,2,3-triazole-4-carboxylic+acid'>YOJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m2n OCA], [https://pdbe.org/7m2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m2n RCSB], [https://www.ebi.ac.uk/pdbsum/7m2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m2n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ding J]] | [[Category: Ding J]] | ||
Revision as of 16:04, 18 October 2023
Crystal structure of Human Lactate Dehydrogenase A with Inhibitor Compound 15
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