1ev3

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[[Image:1ev3.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ev3| PDB=1ev3 | SCENE= }}
{{STRUCTURE_1ev3| PDB=1ev3 | SCENE= }}
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'''Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer'''
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===Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer===
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==Overview==
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The structures of three R(6) human insulin hexamers have been determined. Crystals of monoclinic m-cresol-insulin, monoclinic resorcinol-insulin and rhombohedral m-cresol-insulin diffracted to 1. 9, 1.9 and 1.78 A, respectively, and have been refined to residuals of 0.195, 0.179 and 0.200, respectively. In all three structures, a phenolic derivative is found to occupy the phenolic binding site, where it forms hydrogen bonds to the carbonyl O atom of CysA6 and the N atom of CysA11. Two additional phenolic derivative binding sites were identified within or between hexamers. The structures of all three hexamers are nearly identical, although a large displacement of the N-terminus of one B chain in both monoclinic structures results from coordination to a sodium ion which is located between symmetry-related hexamers. Other minor differences in structure arise from differences in packing in the monoclinic cell compared with the rhombohedral cell. Based upon the differences in conformation of the GluB13 side chains in T(6), T(3)R(f)(3) and R(6) hexamers, the deprotonation of these side chains appears to be associated with the T--&gt;R conformational transition.
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(as it appears on PubMed at http://www.pubmed.gov), where 11092919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11092919}}
==About this Structure==
==About this Structure==
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[[Category: 18-a]]
[[Category: 18-a]]
[[Category: R6 hexamer]]
[[Category: R6 hexamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:33:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:04:08 2008''

Revision as of 23:04, 30 June 2008

Image:1ev3.png

Template:STRUCTURE 1ev3

Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer

Template:ABSTRACT PUBMED 11092919

About this Structure

1EV3 is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

R6 hexameric insulin complexed with m-cresol or resorcinol., Smith GD, Ciszak E, Magrum LA, Pangborn WA, Blessing RH, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1541-8. PMID:11092919

Page seeded by OCA on Tue Jul 1 02:04:08 2008

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