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1evh

From Proteopedia

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[[Image:1evh.jpg|left|200px]]
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{{STRUCTURE_1evh| PDB=1evh | SCENE= }}
{{STRUCTURE_1evh| PDB=1evh | SCENE= }}
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'''EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE'''
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===EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE===
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==Overview==
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The Enabled/VASP homology 1 (EVH1; also called WH1) domain is an interaction module found in several proteins implicated in actin-based cell motility. EVH1 domains bind the consensus proline-rich motif FPPPP and are required for targeting the actin assembly machinery to sites of cytoskeletal remodeling. The crystal structure of the mammalian Enabled (Mena) EVH1 domain complexed with a peptide ligand reveals a mechanism of recognition distinct from that used by other proline-binding modules. The EVH1 domain fold is unexpectedly similar to that of the pleckstrin homology domain, a membrane localization module. This finding demonstrates the functional plasticity of the pleckstrin homology fold as a binding scaffold and suggests that membrane association may play an auxiliary role in EVH1 targeting.
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(as it appears on PubMed at http://www.pubmed.gov), where 10338211 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10338211}}
==About this Structure==
==About this Structure==
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[[Category: Actin dynamic]]
[[Category: Actin dynamic]]
[[Category: Molecular recognition]]
[[Category: Molecular recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:33:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:05:00 2008''

Revision as of 23:05, 30 June 2008

Image:1evh.png

Template:STRUCTURE 1evh

EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE

Template:ABSTRACT PUBMED 10338211

About this Structure

1EVH is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly., Prehoda KE, Lee DJ, Lim WA, Cell. 1999 May 14;97(4):471-80. PMID:10338211

Page seeded by OCA on Tue Jul 1 02:05:00 2008

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