1evm

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{{STRUCTURE_1evm| PDB=1evm | SCENE= }}
{{STRUCTURE_1evm| PDB=1evm | SCENE= }}
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'''NMR OBSERVATION OF A-TETRAD'''
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===NMR OBSERVATION OF A-TETRAD===
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==Overview==
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The structure of the telomeric DNA has been a subject of extensive investigation in recent years due to the realization that it has important functional roles to play in vivo and the observations that truncated telomeric sequences exhibit a great variety of 3D structures in aqueous solutions. In this context, we describe here NMR structural studies on two truncated human telomeric DNA sequences, d-AG(3)T and d-TAG(3)T in solutions containing K(+)ions. The G(3)stretches in both the oligonucleotides were seen to form parallel-stranded quadruplexes. However, the AG(3)segment as a whole, had different structural characteristics. The structure of d-AG(3)T revealed the formation of a novel A-tetrad, which was not seen in d-TAG(3)T. The A's in the tetrad had syn glycosidic conformation as opposed to the anti conformation of the G's in the G-tetrads. The A-tetrad stacked well over the adjacent G-tetrad and the twist angle at this step was smaller in d-AG(3)T than in d-TAG(3)T. These observations are expected to be significant from the point of view of structural diversity and recognition in telomeres.
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(as it appears on PubMed at http://www.pubmed.gov), where 10481022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10481022}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVM OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVM OCA].
==Reference==
==Reference==
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[[Category: Human telomere]]
[[Category: Human telomere]]
[[Category: Nmr structure]]
[[Category: Nmr structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:34:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:05:24 2008''

Revision as of 23:05, 30 June 2008

Image:1evm.png

Template:STRUCTURE 1evm

NMR OBSERVATION OF A-TETRAD

Template:ABSTRACT PUBMED 10481022

About this Structure

Full experimental information is available from OCA.

Reference

NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad., Patel PK, Koti AS, Hosur RV, Nucleic Acids Res. 1999 Oct 1;27(19):3836-43. PMID:10481022

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