This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1evr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1evr.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1evr.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1evr| PDB=1evr | SCENE= }}
{{STRUCTURE_1evr| PDB=1evr | SCENE= }}
-
'''The structure of the resorcinol/insulin R6 hexamer'''
+
===The structure of the resorcinol/insulin R6 hexamer===
-
==Overview==
+
<!--
-
The structures of three R(6) human insulin hexamers have been determined. Crystals of monoclinic m-cresol-insulin, monoclinic resorcinol-insulin and rhombohedral m-cresol-insulin diffracted to 1. 9, 1.9 and 1.78 A, respectively, and have been refined to residuals of 0.195, 0.179 and 0.200, respectively. In all three structures, a phenolic derivative is found to occupy the phenolic binding site, where it forms hydrogen bonds to the carbonyl O atom of CysA6 and the N atom of CysA11. Two additional phenolic derivative binding sites were identified within or between hexamers. The structures of all three hexamers are nearly identical, although a large displacement of the N-terminus of one B chain in both monoclinic structures results from coordination to a sodium ion which is located between symmetry-related hexamers. Other minor differences in structure arise from differences in packing in the monoclinic cell compared with the rhombohedral cell. Based upon the differences in conformation of the GluB13 side chains in T(6), T(3)R(f)(3) and R(6) hexamers, the deprotonation of these side chains appears to be associated with the T--&gt;R conformational transition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11092919}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11092919 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11092919}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Smith, G D.]]
[[Category: Smith, G D.]]
[[Category: R6 insulin hexamer]]
[[Category: R6 insulin hexamer]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:34:30 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:05:47 2008''

Revision as of 23:05, 30 June 2008

Image:1evr.png

Template:STRUCTURE 1evr

The structure of the resorcinol/insulin R6 hexamer

Template:ABSTRACT PUBMED 11092919

About this Structure

1EVR is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

R6 hexameric insulin complexed with m-cresol or resorcinol., Smith GD, Ciszak E, Magrum LA, Pangborn WA, Blessing RH, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1541-8. PMID:11092919

Page seeded by OCA on Tue Jul 1 02:05:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1evr"
Personal tools