1e09

<StructureSection load='1e09' size='340' side='right'caption='[[1e09]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cerasus_avium Cerasus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E09 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1btv|1btv]], [[1b6f|1b6f]], [[1bv1|1bv1]]</div></td></tr>

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== Publication Abstract from PubMed ==

Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To provide a basis for examining the cross-reactivity on a structural level, we used heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen allergen, we propose an explanation for a significant aspect of the observed cross-reactivity pattern among the family of allergens under consideration. The large hydrophobic cavity expected to be important for the still unknown physiological function of Bet v 1 is conserved in Pru av 1. Structural homology to a domain of human MLN64 associated with cholesterol transport suggests phytosteroids as putative ligands for Pru av 1. NMR spectroscopy provides experimental evidence that Pru av 1 interacts with phytosteroids, and molecular modeling shows that the hydrophobic cavity is large enough to accommodate two such molecules.

Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1.,Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426<ref>PMID:11287426</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1e09" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Cerasus avium]]

[[Category: Boehm, M]]

[[Category: Nerkamp, J]]

[[Category: Neudecker, P]]

[[Category: Roesch, P]]

[[Category: Scheurer, S]]

[[Category: Schweimer, K]]

[[Category: Sticht, H]]

[[Category: Vieths, S]]

[[Category: Pathogenesis-related protein]]