1epx
From Proteopedia
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<StructureSection load='1epx' size='340' side='right'caption='[[1epx]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1epx' size='340' side='right'caption='[[1epx]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1epx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1epx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana Leishmania mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EPX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epx OCA], [https://pdbe.org/1epx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epx RCSB], [https://www.ebi.ac.uk/pdbsum/1epx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1epx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epx OCA], [https://pdbe.org/1epx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1epx RCSB], [https://www.ebi.ac.uk/pdbsum/1epx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1epx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9U5N6_LEIME Q9U5N6_LEIME] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epx ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1epx ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Trypanosomatids, unicellular organisms responsible for several global diseases, contain unique organelles called glycosomes in which the first seven glycolytic enzymes are sequestered. We report the crystal structures of glycosomal fructose-1,6-bisphosphate aldolase from two major tropical pathogens, Trypanosoma brucei and Leishmania mexicana, the causative agents of African sleeping sickness and one form of leishmaniasis, respectively. Unlike mammalian aldolases, the T. brucei and L. mexicana aldolases contain nonameric N-terminal type 2 peroxisomal targeting signals (PTS2s) to direct their import into the glycosome. In both tetrameric trypanosomatid aldolases, the PTS2s from two different subunits form two closely intertwined structures. These "PTS2 dimers", which have very similar conformations in the two aldolase structures, are the first reported conformations of a glycosomal or peroxisomal PTS2, and provide opportunities for the design of trypanocidal compounds. | ||
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| - | Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases.,Chudzik DM, Michels PA, de Walque S, Hol WG J Mol Biol. 2000 Jul 21;300(4):697-707. PMID:10891264<ref>PMID:10891264</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1epx" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Aldolase 3D structures|Aldolase 3D structures]] | *[[Aldolase 3D structures|Aldolase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Fructose-bisphosphate aldolase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Leishmania mexicana]] |
| - | [[Category: Chudzik | + | [[Category: Chudzik DM]] |
| - | [[Category: Hol | + | [[Category: Hol WGJ]] |
| - | [[Category: Michels | + | [[Category: Michels PA]] |
| - | [[Category: Walque | + | [[Category: De Walque S]] |
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Current revision
CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM L. MEXICANA
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