1eww

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[[Image:1eww.jpg|left|200px]]
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{{Seed}}
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[[Image:1eww.png|left|200px]]
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{{STRUCTURE_1eww| PDB=1eww | SCENE= }}
{{STRUCTURE_1eww| PDB=1eww | SCENE= }}
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'''SOLUTION STRUCTURE OF SPRUCE BUDWORM ANTIFREEZE PROTEIN AT 30 DEGREES CELSIUS'''
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===SOLUTION STRUCTURE OF SPRUCE BUDWORM ANTIFREEZE PROTEIN AT 30 DEGREES CELSIUS===
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==Overview==
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Insect antifreeze proteins (AFP) are considerably more active at inhibiting ice crystal growth than AFP from fish or plants. Several insect AFPs, also known as thermal hysteresis proteins, have been cloned and expressed. Their maximum activity is 3-4 times that of fish AFPs and they are 10-100 times more effective at micromolar concentrations. Here we report the solution structure of spruce budworm (Choristoneura fumiferana) AFP and characterize its ice-binding properties. The 9-kDa AFP is a beta-helix with a triangular cross-section and rectangular sides that form stacked parallel beta-sheets; a fold which is distinct from the three known fish AFP structures. The ice-binding side contains 9 of the 14 surface-accessible threonines organized in a regular array of TXT motifs that match the ice lattice on both prism and basal planes. In support of this model, ice crystal morphology and ice-etching experiments are consistent with AFP binding to both of these planes and thus may explain the greater activity of the spruce budworm antifreeze.
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(as it appears on PubMed at http://www.pubmed.gov), where 10917537 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10917537}}
==About this Structure==
==About this Structure==
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1EWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Choristoneura_fumiferana Choristoneura fumiferana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWW OCA].
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1EWW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Choristoneura_fumiferana Choristoneura fumiferana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EWW OCA].
==Reference==
==Reference==
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[[Category: Ice]]
[[Category: Ice]]
[[Category: Insect]]
[[Category: Insect]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:36:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:08:26 2008''

Revision as of 23:08, 30 June 2008

Image:1eww.png

Template:STRUCTURE 1eww

SOLUTION STRUCTURE OF SPRUCE BUDWORM ANTIFREEZE PROTEIN AT 30 DEGREES CELSIUS

Template:ABSTRACT PUBMED 10917537

About this Structure

1EWW is a Single protein structure of sequence from Choristoneura fumiferana. Full experimental information is available from OCA.

Reference

Beta-helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect., Graether SP, Kuiper MJ, Gagne SM, Walker VK, Jia Z, Sykes BD, Davies PL, Nature. 2000 Jul 20;406(6793):325-8. PMID:10917537

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