Ferric-binding protein
From Proteopedia
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== Function == | == Function == | ||
| - | The process of bacterial multiplication requires the acquisition of growth-essential nutrients including iron, from the host cell. '''Ferric-binding protein''' or '''iron binding protein''' (FBP) transfers iron across the periplasmic space from human transferrin to pathogenic bacteria<ref>PMID:7934822</ref>. | + | The process of bacterial multiplication requires the acquisition of growth-essential nutrients including iron, from the host cell. '''Ferric-binding protein''' or '''iron binding protein''' or '''periplasmic iron binding protein'''(FBP) transfers iron across the periplasmic space from human transferrin to pathogenic bacteria<ref>PMID:7934822</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:30, 25 July 2021
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3D Structures of ferric-binding protein
Updated on 25-July-2021
1mrp, 3od7, 3odb – HiFBP + Fe – Haemophilus influenzae
1d9v – HiFBP
1nnf, 1qvs, 1qw0, 2o68, 2o69, 2o6a, 3kn7, 3kn8 - HiFBP (mutant) + Fe
1r1n – NgFBP + oxo-Fe – Neisseria gonorrhoeae
1xc1 – NgFBP + oxo-Zr
3tyh – NgFBP + oxo-Cu
1q35 – FBP – Mannheimia haemolytica
4elo, 4elp, 4elq – TtFBP – Thermus thermophilus
4elr – TtFBP + Fe
6iwf – PaFBP – Pseudomonas aeruginosa
6ivy – PaFBP + Fe
6j2s – PaFBP + Ga
6mfl – FBP + Fe + acinetobactin – Acinetobacter baumannii
References
- ↑ Chen CY, Berish SA, Morse SA, Mietzner TA. The ferric iron-binding protein of pathogenic Neisseria spp. functions as a periplasmic transport protein in iron acquisition from human transferrin. Mol Microbiol. 1993 Oct;10(2):311-8. PMID:7934822
- ↑ Khambati HK, Moraes TF, Singh J, Shouldice SR, Yu RH, Schryvers AB. The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric binding protein A. Biochem J. 2010 Aug 27. PMID:20799927 doi:10.1042/BJ20101043
