7b1z
From Proteopedia
(Difference between revisions)
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==Virulence-associated protein VapB from the intracellular pathogen Rhodococcus equi== | ==Virulence-associated protein VapB from the intracellular pathogen Rhodococcus equi== | ||
| - | <StructureSection load='7b1z' size='340' side='right'caption='[[7b1z]]' scene=''> | + | <StructureSection load='7b1z' size='340' side='right'caption='[[7b1z]], [[Resolution|resolution]] 1.71Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B1Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7b1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_equi Rhodococcus equi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B1Z FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b1z OCA], [https://pdbe.org/7b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b1z RCSB], [https://www.ebi.ac.uk/pdbsum/7b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b1z ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b1z OCA], [https://pdbe.org/7b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b1z RCSB], [https://www.ebi.ac.uk/pdbsum/7b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b1z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B4F366_RHOHA B4F366_RHOHA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Virulence-associated proteins (Vaps) contribute to the virulence of the pathogen Rhodococcus equi, but their mode of action has remained elusive. All Vaps share a conserved core of about 105 amino acids that folds into a compact eight-stranded antiparallel beta-barrel with a unique topology. At the top of the barrel, four loops connect the eight beta-strands. Previous Vap structures did not show concave surfaces that might serve as a ligand-binding site. Here, the structure of VapB in a new crystal form was determined at 1.71 A resolution. The asymmetric unit contains two molecules. In one of them, the loop regions at the top of the barrel adopt a different conformation from other Vap structures. An outward movement of the loops results in the formation of a hydrophobic cavity that might act as a ligand-binding site. This lends further support to the hypothesis that the structural similarity between Vaps and avidins suggests a potential binding function for Vaps. | ||
| + | |||
| + | Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB.,Geerds C, Haas A, Niemann HH Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):246-253. doi: , 10.1107/S2053230X2100738X. Epub 2021 Jul 28. PMID:34341190<ref>PMID:34341190</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7b1z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Rhodococcus equi]] | ||
[[Category: Geerds C]] | [[Category: Geerds C]] | ||
[[Category: Niemann HH]] | [[Category: Niemann HH]] | ||
Current revision
Virulence-associated protein VapB from the intracellular pathogen Rhodococcus equi
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