1fo1

<table><tr><td colspan='2'>[[1fo1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FO1 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fo1 OCA], [https://pdbe.org/1fo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1fo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fo1 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/NXF1_HUMAN NXF1_HUMAN]] Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.<ref>PMID:9660949</ref> <ref>PMID:19165146</ref>

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== Publication Abstract from PubMed ==

Human TAP is implicated in mRNA nuclear export and is used by simian type D retroviruses to export their unspliced genomic RNA to the cytoplasm of the host cell. We have determined the crystal structure of the minimal TAP fragment that binds the constitutive transport element (CTE) of retroviral RNAs. Unexpectedly, we find the fragment consists of a ribonucleoprotein (RNP) domain, which is not identifiable by its sequence, and a leucine-rich repeat (LRR) domain. The non-canonical RNP domain functions as the general RNA-binding portion of the fragment. The LRR domain is required in cis to the RNP domain for CTE RNA binding. The structural and biochemical properties of the domains point to a remarkable similarity with the U2B"(RNP)-U2A'(LRR) spliceosomal heterodimer. Our in vitro and in vivo functional studies using structure-based mutants suggest that a phylogenetically conserved surface of the LRR domain of TAP may have different roles in the export of viral and cellular RNAs.

The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain.,Liker E, Fernandez E, Izaurralde E, Conti E EMBO J. 2000 Nov 1;19(21):5587-98. PMID:11060011<ref>PMID:11060011</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1fo1" style="background-color:#fffaf0;"></div>

[[Category: Human]]

[[Category: Conti, E]]

[[Category: Fernandez, E]]

[[Category: Izaurralde, E]]

[[Category: Liker, E]]

[[Category: Rna binding protein]]