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1eyo

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{{STRUCTURE_1eyo| PDB=1eyo | SCENE= }}
{{STRUCTURE_1eyo| PDB=1eyo | SCENE= }}
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'''SOLUTION STRUCTURE OF CONOTOXIN TVIIA FROM CONUS TULIPA'''
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===SOLUTION STRUCTURE OF CONOTOXIN TVIIA FROM CONUS TULIPA===
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==Overview==
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The three-dimensional solution structure of conotoxin TVIIA, a 30-residue polypeptide from the venom of the piscivorous cone snail Conus tulipa, has been determined using 2D 1H NMR spectroscopy. TVIIA contains six cysteine residues which form a 'four-loop' structural framework common to many peptides from Conus venoms including the omega-, delta-, kappa-, and muO-conotoxins. However, TVIIA does not belong to these well-characterized pharmacological classes of conotoxins, but displays high sequence identity with conotoxin GS, a muscle sodium channel blocker from Conus geographus. Structure calculations were based on 562 interproton distance restraints inferred from NOE data, together with 18 backbone and nine side-chain torsion angle restraints derived from spin-spin coupling constants. The final family of 20 structures had mean pairwise rms differences over residues 2-27 of 0.18+/-0.05 A for the backbone atoms and 1.39+/-0.33 A for all heavy atoms. The structure consists of a triple-stranded, antiparallel beta sheet with +2x, -1 topology (residues 7-9, 16-20 and 23-27) and several beta turns. The core of the molecule is formed by three disulfide bonds which form a cystine knot motif common to many toxic and inhibitory polypeptides. The global fold, molecular shape and distribution of amino-acid sidechains in TVIIA is similar to that previously reported for conotoxin GS, and comparison with other four-loop conotoxin structures provides further indication that TVIIA and GS represent a new and distinct subgroup of this structural family. The structure of TVIIA determined in this study provides the basis for determining a structure-activity relationship for these molecules and their interaction with target receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 10903497 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10903497}}
==About this Structure==
==About this Structure==
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1EYO is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYO OCA].
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1EYO is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYO OCA].
==Reference==
==Reference==
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[[Category: Hill, J M.]]
[[Category: Hill, J M.]]
[[Category: Cystine knot motif]]
[[Category: Cystine knot motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:40:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:13:18 2008''

Revision as of 23:13, 30 June 2008

Image:1eyo.png

Template:STRUCTURE 1eyo

SOLUTION STRUCTURE OF CONOTOXIN TVIIA FROM CONUS TULIPA

Template:ABSTRACT PUBMED 10903497

About this Structure

1EYO is a Single protein structure. Full experimental information is available from OCA.

Reference

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure., Hill JM, Alewood PF, Craik DJ, Eur J Biochem. 2000 Aug;267(15):4649-57. PMID:10903497

Page seeded by OCA on Tue Jul 1 02:13:18 2008

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