1bke
From Proteopedia
(New page: 200px<br /> <applet load="1bke" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bke, resolution 3.15Å" /> '''HUMAN SERUM ALBUMIN...) |
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| - | [[Image:1bke.gif|left|200px]]<br /> | + | [[Image:1bke.gif|left|200px]]<br /><applet load="1bke" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bke" size=" | + | |
caption="1bke, resolution 3.15Å" /> | caption="1bke, resolution 3.15Å" /> | ||
'''HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID'''<br /> | '''HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human serum albumin (HSA) is the most abundant protein in the circulatory | + | Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs. Despite intensive efforts, the detailed structural basis of fatty acid binding to HSA has remained elusive. We have now determined the crystal structure of HSA complexed with five molecules of myristate at 2.5 A resolution. The fatty acid molecules bind in long, hydrophobic pockets capped by polar side chains, many of which are basic. These pockets are distributed asymmetrically throughout the HSA molecule, despite its symmetrical repeating domain structure. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MYR and B3I as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1BKE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MYR:'>MYR</scene> and <scene name='pdbligand=B3I:'>B3I</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BKE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: plasma protein]] | [[Category: plasma protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:15 2008'' |
Revision as of 09:56, 21 February 2008
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HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID
Contents |
Overview
Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs. Despite intensive efforts, the detailed structural basis of fatty acid binding to HSA has remained elusive. We have now determined the crystal structure of HSA complexed with five molecules of myristate at 2.5 A resolution. The fatty acid molecules bind in long, hydrophobic pockets capped by polar side chains, many of which are basic. These pockets are distributed asymmetrically throughout the HSA molecule, despite its symmetrical repeating domain structure.
Disease
Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]
About this Structure
1BKE is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites., Curry S, Mandelkow H, Brick P, Franks N, Nat Struct Biol. 1998 Sep;5(9):827-35. PMID:9731778
Page seeded by OCA on Thu Feb 21 11:56:15 2008
Categories: Homo sapiens | Single protein | Brick, P. | Curry, S. | Franks, N. | Mandelkow, H. | B3I | MYR | Lipid-binding | Metal-binding | Plasma protein
