1ezg

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{{STRUCTURE_1ezg| PDB=1ezg | SCENE= }}
{{STRUCTURE_1ezg| PDB=1ezg | SCENE= }}
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'''CRYSTAL STRUCTURE OF ANTIFREEZE PROTEIN FROM THE BEETLE, TENEBRIO MOLITOR'''
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===CRYSTAL STRUCTURE OF ANTIFREEZE PROTEIN FROM THE BEETLE, TENEBRIO MOLITOR===
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==Overview==
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Insect antifreeze proteins (AFP) are much more effective than fish AFPs at depressing solution freezing points by ice-growth inhibition. AFP from the beetle Tenebrio molitor is a small protein (8.4 kDa) composed of tandem 12-residue repeats (TCTxSxxCxxAx). Here we report its 1.4-A resolution crystal structure, showing that this repetitive sequence translates into an exceptionally regular beta-helix. Not only are the 12-amino-acid loops almost identical in the backbone, but also the conserved side chains are positioned in essentially identical orientations, making this AFP perhaps the most regular protein structure yet observed. The protein has almost no hydrophobic core but is stabilized by numerous disulphide and hydrogen bonds. On the conserved side of the protein, threonine-cysteine-threonine motifs are arrayed to form a flat beta-sheet, the putative ice-binding surface. The threonine side chains have exactly the same rotameric conformation and the spacing between OH groups is a near-perfect match to the ice lattice. Together with tightly bound co-planar external water, three ranks of oxygen atoms form a two-dimensional array, mimicking an ice section.
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(as it appears on PubMed at http://www.pubmed.gov), where 10917536 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10917536}}
==About this Structure==
==About this Structure==
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[[Category: Thermal hysteresis]]
[[Category: Thermal hysteresis]]
[[Category: Tmafp]]
[[Category: Tmafp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:42:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:15:20 2008''

Revision as of 23:15, 30 June 2008

Image:1ezg.png

Template:STRUCTURE 1ezg

CRYSTAL STRUCTURE OF ANTIFREEZE PROTEIN FROM THE BEETLE, TENEBRIO MOLITOR

Template:ABSTRACT PUBMED 10917536

About this Structure

1EZG is a Single protein structure of sequence from Tenebrio molitor. Full crystallographic information is available from OCA.

Reference

Mimicry of ice structure by surface hydroxyls and water of a beta-helix antifreeze protein., Liou YC, Tocilj A, Davies PL, Jia Z, Nature. 2000 Jul 20;406(6793):322-4. PMID:10917536

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