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1izh

From Proteopedia

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Current revision (07:13, 25 October 2023) (edit) (undo)
 
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<StructureSection load='1izh' size='340' side='right'caption='[[1izh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1izh' size='340' side='right'caption='[[1izh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1izh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1izi|1izi]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q50:{(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>Q50</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izh OCA], [https://pdbe.org/1izh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izh RCSB], [https://www.ebi.ac.uk/pdbsum/1izh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1izh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1izh OCA], [https://pdbe.org/1izh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1izh RCSB], [https://www.ebi.ac.uk/pdbsum/1izh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1izh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q90EB9_9HIV1 Q90EB9_9HIV1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: HIV-1 retropepsin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hilgenfeld, R]]
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[[Category: Hilgenfeld R]]
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[[Category: Klimkait, T]]
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[[Category: Klimkait T]]
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[[Category: Konvalinka, J]]
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[[Category: Konvalinka J]]
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[[Category: Kraeusslich, H G]]
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[[Category: Kraeusslich H-G]]
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[[Category: Lepsik, M]]
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[[Category: Lepsik M]]
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[[Category: Machala, L]]
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[[Category: Machala L]]
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[[Category: Mesters, J R]]
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[[Category: Mesters JR]]
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[[Category: Mlcochova, P]]
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[[Category: Mlcochova P]]
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[[Category: Prejdova, J]]
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[[Category: Prejdova J]]
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[[Category: Skalicka, K]]
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[[Category: Skalicka K]]
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[[Category: Soucek, M]]
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[[Category: Soucek M]]
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[[Category: Sponarova, J]]
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[[Category: Sponarova J]]
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[[Category: Stankova, M]]
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[[Category: Stankova M]]
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[[Category: Strisovsky, K]]
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[[Category: Strisovsky K]]
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[[Category: Svec, M]]
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[[Category: Svec M]]
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[[Category: Uhlikova, T]]
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[[Category: Uhlikova T]]
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[[Category: Vondrasek, J]]
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[[Category: Vondrasek J]]
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[[Category: Weber, J]]
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[[Category: Weber J]]
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[[Category: Hiv-1 proteinase]]
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[[Category: Hydrolase]]
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[[Category: Potent inhibitor]]
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[[Category: Subsite binding]]
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Current revision

Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants

PDB ID 1izh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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