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1j3i

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Current revision (23:41, 27 December 2023) (edit) (undo)
 
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<StructureSection load='1j3i' size='340' side='right'caption='[[1j3i]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='1j3i' size='340' side='right'caption='[[1j3i]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1j3i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1j3i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J3I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>, <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j3j|1j3j]], [[1j3k|1j3k]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>, <scene name='pdbligand=WRA:6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>WRA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3i OCA], [https://pdbe.org/1j3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j3i RCSB], [https://www.ebi.ac.uk/pdbsum/1j3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j3i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3i OCA], [https://pdbe.org/1j3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j3i RCSB], [https://www.ebi.ac.uk/pdbsum/1j3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j3i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
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[https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plafa]]
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[[Category: Plasmodium falciparum]]
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[[Category: Chitnumsub, P]]
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[[Category: Chitnumsub P]]
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[[Category: Kamchonwongpaisan, S]]
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[[Category: Kamchonwongpaisan S]]
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[[Category: Sirawaraporn, W]]
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[[Category: Sirawaraporn W]]
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[[Category: Taylor, P]]
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[[Category: Taylor P]]
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[[Category: Vanichtanankul, J]]
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[[Category: Vanichtanankul J]]
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[[Category: Walkinshaw, M]]
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[[Category: Walkinshaw M]]
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[[Category: Yuthavong, Y]]
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[[Category: Yuthavong Y]]
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[[Category: Yuvaniyama, J]]
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[[Category: Yuvaniyama J]]
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[[Category: Bifunctional]]
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[[Category: Oxidoreductase]]
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[[Category: Transferase]]
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Current revision

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP

PDB ID 1j3i

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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