Glucose-dependent Insulinotropic Polypeptide Receptor

GIP-induced Pathway.^[1]

Introduction

Glucose-dependent insulinotropic polypeptide receptor or gastric inhibitory polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose.

Molecular Function

The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though and triggering activation of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin^[2]. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.

Ongoing Research

The significance of this receptor makes it a prime target for Diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta^[3].