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1f0z

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[[Image:1f0z.jpg|left|200px]]
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{{STRUCTURE_1f0z| PDB=1f0z | SCENE= }}
{{STRUCTURE_1f0z| PDB=1f0z | SCENE= }}
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'''SOLUTION STRUCTURE OF THIS, THE SULFUR CARRIER PROTEIN IN E.COLI THIAMIN BIOSYNTHESIS'''
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===SOLUTION STRUCTURE OF THIS, THE SULFUR CARRIER PROTEIN IN E.COLI THIAMIN BIOSYNTHESIS===
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==Overview==
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ThiS is a sulfur carrier protein that plays a central role in thiamin biosynthesis in Escherichia coli. Here we report the solution NMR structure of ThiS, the first for this class of sulfur carrier proteins. Although ThiS shares only 14% sequence identity with ubiquitin, it possesses the ubiquitin fold. This structural homology, combined with established functional similarities involving sulfur chemistry, demonstrates that the eukaryotic ubiquitin and the prokaryotic ThiS evolved from a common ancestor. This illustrates how structure determination is essential in establishing evolutionary links between proteins in which structure and function have been conserved through eons of evolution despite loss of sequence identity. The ThiS structure reveals both hydrophobic and electrostatic surface features that are likely determinants for interactions with binding partners. Comparison with surface features of ubiquitin and ubiquitin homologs SUMO-1, RUB-1 and NEDD8 suggest how Nature has utilized this single fold to incorporate similar chemistry into a broad array of highly specific biological processes.
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The line below this paragraph, {{ABSTRACT_PUBMED_11135670}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11135670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11135670}}
==About this Structure==
==About this Structure==
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1F0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0Z OCA].
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1F0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0Z OCA].
==Reference==
==Reference==
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[[Category: Xi, J.]]
[[Category: Xi, J.]]
[[Category: Ubiquitin fold]]
[[Category: Ubiquitin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:45:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:19:18 2008''

Revision as of 23:19, 30 June 2008

Image:1f0z.png

Template:STRUCTURE 1f0z

SOLUTION STRUCTURE OF THIS, THE SULFUR CARRIER PROTEIN IN E.COLI THIAMIN BIOSYNTHESIS

Template:ABSTRACT PUBMED 11135670

About this Structure

1F0Z is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of ThiS and implications for the evolutionary roots of ubiquitin., Wang C, Xi J, Begley TP, Nicholson LK, Nat Struct Biol. 2001 Jan;8(1):47-51. PMID:11135670

Page seeded by OCA on Tue Jul 1 02:19:18 2008

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