1f1e

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{{STRUCTURE_1f1e| PDB=1f1e | SCENE= }}
{{STRUCTURE_1f1e| PDB=1f1e | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HISTONE FROM METHANOPYRUS KANDLERI'''
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===CRYSTAL STRUCTURE OF THE HISTONE FROM METHANOPYRUS KANDLERI===
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==Overview==
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Eukaryotic histone proteins condense DNA into compact structures called nucleosomes. Nucleosomes were viewed as a distinguishing feature of eukaryotes prior to identification of histone orthologs in methanogens. Although evolutionarily distinct from methanogens, the methane-producing hyperthermophile Methanopyrus kandleri produces a novel, 154-residue histone (HMk). Amino acid sequence comparisons show that HMk differs from both methanogenic and eukaryotic histones, in that it contains two histone-fold ms within a single chain. The two HMk histone-fold ms, N and C terminal, are 28% identical in amino acid sequence to each other and approximately 21% identical in amino acid sequence to other histone proteins. Here we present the 1.37-A-resolution crystal structure of HMk and report that the HMk monomer structure is homologous to the eukaryotic histone heterodimers. In the crystal, HMk forms a dimer homologous to [H3-H4](2) in the eukaryotic nucleosome. Based on the spatial similarities to structural ms found in the eukaryotic nucleosome that are important for DNA-binding, we infer that the Methanopyrus histone binds DNA in a manner similar to the eukaryotic histone tetramer [H3-H4](2).
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{{ABSTRACT_PUBMED_11567091}}
==About this Structure==
==About this Structure==
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[[Category: Slesarev, A.]]
[[Category: Slesarev, A.]]
[[Category: Archaeal histone protein]]
[[Category: Archaeal histone protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:20:17 2008''

Revision as of 23:20, 30 June 2008

Image:1f1e.png

Template:STRUCTURE 1f1e

CRYSTAL STRUCTURE OF THE HISTONE FROM METHANOPYRUS KANDLERI

Template:ABSTRACT PUBMED 11567091

About this Structure

1F1E is a Single protein structure of sequence from Methanopyrus kandleri. Full crystallographic information is available from OCA.

Reference

An ancestral nuclear protein assembly: crystal structure of the Methanopyrus kandleri histone., Fahrner RL, Cascio D, Lake JA, Slesarev A, Protein Sci. 2001 Oct;10(10):2002-7. PMID:11567091

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