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1j72

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Current revision (07:37, 7 February 2024) (edit) (undo)
 
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<StructureSection load='1j72' size='340' side='right'caption='[[1j72]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1j72' size='340' side='right'caption='[[1j72]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1j72]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J72 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1j72]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J72 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j72 OCA], [https://pdbe.org/1j72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j72 RCSB], [https://www.ebi.ac.uk/pdbsum/1j72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j72 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j72 OCA], [https://pdbe.org/1j72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j72 RCSB], [https://www.ebi.ac.uk/pdbsum/1j72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j72 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CAPG_HUMAN CAPG_HUMAN]] Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
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[https://www.uniprot.org/uniprot/CAPG_HUMAN CAPG_HUMAN] Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Southwick, F S]]
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[[Category: Southwick FS]]
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[[Category: Storokopytov, B]]
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[[Category: Storokopytov B]]
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[[Category: Vorobiev, S M]]
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[[Category: Vorobiev SM]]
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[[Category: Actin]]
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[[Category: Cap g]]
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[[Category: Capping]]
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[[Category: Gcap39]]
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[[Category: Gelsolin]]
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[[Category: Macrophage]]
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[[Category: Mbhl]]
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[[Category: Structural protein]]
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Current revision

Crystal Structure of Mutant Macrophage Capping Protein (Cap G) with Actin-severing Activity in the Ca2+-Free Form

PDB ID 1j72

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