1f1m

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[[Image:1f1m.gif|left|200px]]
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{{Seed}}
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[[Image:1f1m.png|left|200px]]
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{{STRUCTURE_1f1m| PDB=1f1m | SCENE= }}
{{STRUCTURE_1f1m| PDB=1f1m | SCENE= }}
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'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)'''
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===CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)===
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==Overview==
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Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.
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The line below this paragraph, {{ABSTRACT_PUBMED_11230121}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11230121 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11230121}}
==About this Structure==
==About this Structure==
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[[Category: Lyme disease]]
[[Category: Lyme disease]]
[[Category: Ospc]]
[[Category: Ospc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:20:34 2008''

Revision as of 23:20, 30 June 2008

Image:1f1m.png

Template:STRUCTURE 1f1m

CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)

Template:ABSTRACT PUBMED 11230121

About this Structure

1F1M is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi., Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S, EMBO J. 2001 Mar 1;20(5):971-8. PMID:11230121

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