1kac

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<StructureSection load='1kac' size='340' side='right'caption='[[1kac]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1kac' size='340' side='right'caption='[[1kac]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ade12 Ade12] and [https://en.wikipedia.org/wiki/Human Human]. The December 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KAC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kac]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_adenovirus_12 Human adenovirus 12]. The December 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KAC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nob|1nob]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kac OCA], [https://pdbe.org/1kac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kac RCSB], [https://www.ebi.ac.uk/pdbsum/1kac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kac ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kac OCA], [https://pdbe.org/1kac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kac RCSB], [https://www.ebi.ac.uk/pdbsum/1kac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kac ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPIKE_ADE12 SPIKE_ADE12]] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity). [[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
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[https://www.uniprot.org/uniprot/SPIKE_ADE12 SPIKE_ADE12] Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CXCAR to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ade12]]
 
[[Category: Adenovirus]]
[[Category: Adenovirus]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Human adenovirus 12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Bewley, M C]]
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[[Category: Bewley MC]]
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[[Category: Flanagan, J M]]
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[[Category: Flanagan JM]]
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[[Category: Freimuth, P]]
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[[Category: Freimuth P]]
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[[Category: Springer, K]]
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[[Category: Springer K]]
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[[Category: Zhang, Y B]]
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[[Category: Zhang YB]]
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[[Category: Adhesion protein receptor complex]]
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[[Category: Viral protein-receptor complex]]
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Revision as of 23:43, 27 December 2023

KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12 IN COMPLEX WITH DOMAIN 1 OF ITS CELLULAR RECEPTOR CAR

PDB ID 1kac

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