1bnl
From Proteopedia
(New page: 200px<br /> <applet load="1bnl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bnl, resolution 2.9Å" /> '''ZINC DEPENDENT DIMER...) |
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| - | [[Image:1bnl.gif|left|200px]]<br /> | + | [[Image:1bnl.gif|left|200px]]<br /><applet load="1bnl" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bnl" size=" | + | |
caption="1bnl, resolution 2.9Å" /> | caption="1bnl, resolution 2.9Å" /> | ||
'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''<br /> | '''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of human endostatin reveals a zinc-binding site. | + | The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1BNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BNL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Boehm, T.]] | [[Category: Boehm, T.]] | ||
[[Category: Chopra, R.]] | [[Category: Chopra, R.]] | ||
| - | [[Category: Ding, Y | + | [[Category: Ding, Y H.]] |
[[Category: Folkman, J.]] | [[Category: Folkman, J.]] | ||
| - | [[Category: Harris, B | + | [[Category: Harris, B A.]] |
[[Category: Hohenester, E.]] | [[Category: Hohenester, E.]] | ||
[[Category: Javaherian, K.]] | [[Category: Javaherian, K.]] | ||
[[Category: Lanciotti, J.]] | [[Category: Lanciotti, J.]] | ||
[[Category: Li, Y.]] | [[Category: Li, Y.]] | ||
| - | [[Category: Lo, K | + | [[Category: Lo, K M.]] |
[[Category: Shapiro, R.]] | [[Category: Shapiro, R.]] | ||
[[Category: Timpl, R.]] | [[Category: Timpl, R.]] | ||
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: angiogenic]] | [[Category: angiogenic]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:06 2008'' |
Revision as of 09:57, 21 February 2008
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ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN
Contents |
Overview
The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself.
Disease
Known disease associated with this structure: Knobloch syndrome OMIM:[120328]
About this Structure
1BNL is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:9724722
Page seeded by OCA on Thu Feb 21 11:57:06 2008
Categories: Homo sapiens | Single protein | Boehm, T. | Chopra, R. | Ding, Y H. | Folkman, J. | Harris, B A. | Hohenester, E. | Javaherian, K. | Lanciotti, J. | Li, Y. | Lo, K M. | Shapiro, R. | Timpl, R. | Wiley, D C. | ZN | Angiogenic | Angiogenisis | Antiangiogenic | Cancer | Collagen | Collagen xviii | Endostatin | Extracellular matrix | Zinc
