7csm
From Proteopedia
(Difference between revisions)
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==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant== | ==Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant== | ||
| - | <StructureSection load='7csm' size='340' side='right'caption='[[7csm]]' scene=''> | + | <StructureSection load='7csm' size='340' side='right'caption='[[7csm]], [[Resolution|resolution]] 1.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7csm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulto Sulto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CSM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csm OCA], [https://pdbe.org/7csm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csm RCSB], [https://www.ebi.ac.uk/pdbsum/7csm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csm ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ogt, STK_09670 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273063 SULTO])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7csm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7csm OCA], [https://pdbe.org/7csm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7csm RCSB], [https://www.ebi.ac.uk/pdbsum/7csm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7csm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Iizuka Y]] | + | [[Category: Sulto]] |
| - | [[Category: Kikuchi M]] | + | [[Category: Iizuka, Y]] |
| - | [[Category: Tsunoda M]] | + | [[Category: Kikuchi, M]] |
| - | [[Category: Yamauchi T]] | + | [[Category: Tsunoda, M]] |
| + | [[Category: Yamauchi, T]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 16:55, 15 December 2021
Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant
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