1f2s

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[[Image:1f2s.jpg|left|200px]]
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[[Image:1f2s.png|left|200px]]
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==Overview==
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{{ABSTRACT_10524768}}
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The stoichiometric complex formed between bovine beta-trypsin and Momordica charantia, Linn. Cucurbitaceae trypsin inhibitor A (MCTI-A) was crystallized and its X-ray crystal structure was refined to a final R value of 0.179 using data of 7.0- to 1.8-A resolution. Combination with results on the complex of MCTI-A with porcine trypsin gives the sequence of MCTI-A definitely, of which 13 residues are conserved compared with other squash family trypsin inhibitors. Its spatial structure and the conformation of its primary binding segment from Cys3I (P3) to Glu7I (P3'), which contains a reactive scissile bond Arg5I C-Ile6I N, were found to be very similar to the other squash family proteinase inhibitors.
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==About this Structure==
==About this Structure==
1F2S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mcu 1mcu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2S OCA].
1F2S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mcu 1mcu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2S OCA].
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==Reference==
 
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Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution., Zhu Y, Huang Q, Qian M, Jia Y, Tang Y, J Protein Chem. 1999 Jul;18(5):505-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10524768 10524768]
 
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Momordica charantia]]
[[Category: Momordica charantia]]
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[[Category: Proteinase-inhibitor complex]]
[[Category: Proteinase-inhibitor complex]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 19:20:59 2008''

Revision as of 16:21, 25 June 2008

Image:1f2s.png

Template:STRUCTURE 1f2s

CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION


Template:ABSTRACT 10524768

About this Structure

1F2S is a Protein complex structure of sequences from Bos taurus and Momordica charantia. This structure supersedes the now removed PDB entry 1mcu. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 19:20:59 2008

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