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7o1p

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Current revision (12:43, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7o1p' size='340' side='right'caption='[[7o1p]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='7o1p' size='340' side='right'caption='[[7o1p]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7o1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O1P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7o1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O1P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7o1o|7o1o]], [[7o1s|7o1s]], [[7o1t|7o1t]], [[7o25|7o25]], [[7o26|7o26]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TM_1269, THEMA_07990, Tmari_1274 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o1p OCA], [https://pdbe.org/7o1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o1p RCSB], [https://www.ebi.ac.uk/pdbsum/7o1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o1p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o1p OCA], [https://pdbe.org/7o1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o1p RCSB], [https://www.ebi.ac.uk/pdbsum/7o1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o1p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HYDE_THEMA HYDE_THEMA]] Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster (PubMed:16137685).[UniProtKB:Q97IK9]<ref>PMID:16137685</ref>
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[https://www.uniprot.org/uniprot/HYDE_THEMA HYDE_THEMA] Required for the maturation of the [FeFe]-hydrogenase HydA (By similarity). Catalyzes the reductive cleavage of S-adenosyl-L-methionine (in vitro), suggesting it may contribute to the biosynthesis of an essential sulfur-containing ligand that binds to the hydrogenase active site [2Fe-2S] cluster (PubMed:16137685).[UniProtKB:Q97IK9]<ref>PMID:16137685</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thema]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Basu, D]]
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[[Category: Basu D]]
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[[Category: Britt, R D]]
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[[Category: Britt RD]]
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[[Category: Liu, L]]
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[[Category: Liu L]]
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[[Category: Martin, L]]
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[[Category: Martin L]]
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[[Category: Nicolet, Y]]
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[[Category: Nicolet Y]]
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[[Category: Rauchfuss, T]]
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[[Category: Rauchfuss T]]
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[[Category: Rohac, R]]
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[[Category: Rohac R]]
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[[Category: Tao, L]]
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[[Category: Tao L]]
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[[Category: Hydrogenase maturase]]
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[[Category: Metal binding protein]]
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[[Category: Metalloprotein]]
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[[Category: Radical sam protein]]
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Current revision

[FeFe]-hydrogenase maturase HydE from T. Maritima (C-ter stretch absent)

PDB ID 7o1p

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OCA

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