1f39

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{{STRUCTURE_1f39| PDB=1f39 | SCENE= }}
{{STRUCTURE_1f39| PDB=1f39 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN'''
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===CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN===
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==Overview==
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Interactions between transcription factors bound to separate operator sites commonly play an important role in gene regulation by mediating cooperative binding to the DNA. However, few detailed structural models for understanding the molecular basis of such cooperativity are available. The c1 repressor of bacteriophage lambda is a classic example of a protein that binds to its operator sites cooperatively. The C-terminal domain of the repressor mediates dimerization as well as a dimer-dimer interaction that results in the cooperative binding of two repressor dimers to adjacent operator sites. Here, we present the x-ray crystal structure of the lambda repressor C-terminal domain determined by multiwavelength anomalous diffraction. Remarkably, the interactions that mediate cooperativity are captured in the crystal, where two dimers associate about a 2-fold axis of symmetry. Based on the structure and previous genetic and biochemical data, we present a model for the cooperative binding of two lambda repressor dimers at adjacent operator sites.
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==About this Structure==
==About this Structure==
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[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: Reca-mediated self-cleavage]]
[[Category: Reca-mediated self-cleavage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:35:40 2008''

Revision as of 23:35, 30 June 2008

Image:1f39.png

Template:STRUCTURE 1f39

CRYSTAL STRUCTURE OF THE LAMBDA REPRESSOR C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 10892750

About this Structure

1F39 is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding., Bell CE, Frescura P, Hochschild A, Lewis M, Cell. 2000 Jun 23;101(7):801-11. PMID:10892750

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