1f3d

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{{Seed}}
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{{STRUCTURE_1f3d| PDB=1f3d | SCENE= }}
{{STRUCTURE_1f3d| PDB=1f3d | SCENE= }}
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'''CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.'''
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===CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.===
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==Overview==
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The crystal structure of the complex of a catalytic antibody with its cationic hapten at 1.9-A resolution demonstrates that the hapten amidinium group is stabilized through an ionic pair interaction with the carboxylate of a combining-site residue. The location of this carboxylate allows it to act as a general base in an allylic rearrangement. When compared with structures of other antibody complexes in which the positive moiety of the hapten is stabilized mostly by cation-pi interactions, this structure shows that the amidinium moiety is a useful candidate to elicit a carboxylate in an antibody combining site at a predetermined location with respect to the hapten. More generally, this structure highlights the advantage of a bidentate hapten for the programmed positioning of a chemically reactive residue in an antibody through charge complementarity to the hapten.
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(as it appears on PubMed at http://www.pubmed.gov), where 10963661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10963661}}
==About this Structure==
==About this Structure==
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[[Category: Catalytic antibody]]
[[Category: Catalytic antibody]]
[[Category: Haptenic charge]]
[[Category: Haptenic charge]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:50:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:36:19 2008''

Revision as of 23:36, 30 June 2008

Image:1f3d.png

Template:STRUCTURE 1f3d

CATALYTIC ANTIBODY 4B2 IN COMPLEX WITH ITS AMIDINIUM HAPTEN.

Template:ABSTRACT PUBMED 10963661

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural evidence for a programmed general base in the active site of a catalytic antibody., Golinelli-Pimpaneau B, Goncalves O, Dintinger T, Blanchard D, Knossow M, Tellier C, Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9892-5. PMID:10963661

Page seeded by OCA on Tue Jul 1 02:36:19 2008

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