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1f3v

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[[Image:1f3v.gif|left|200px]]
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{{STRUCTURE_1f3v| PDB=1f3v | SCENE= }}
{{STRUCTURE_1f3v| PDB=1f3v | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE N-TERMINAL DOMAIN OF TRADD AND THE TRAF DOMAIN OF TRAF2'''
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===CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE N-TERMINAL DOMAIN OF TRADD AND THE TRAF DOMAIN OF TRAF2===
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==Overview==
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TRAF proteins are major mediators for the cell activation, cell survival, and antiapoptotic functions of the TNF receptor superfamily. They can be recruited to activated TNF receptors either by direct interactions with the receptors or indirectly via the adaptor protein TRADD. We now report the structure of the TRADD-TRAF2 complex, which is highly distinct from receptor-TRAF2 interactions. This interaction is significantly stronger and we show by an in vivo signaling assay that TRAF2 signaling is more readily initiated by TRADD than by direct receptor-TRAF2 interactions. TRADD is specific for TRAF1 and TRAF2, which ensures the recruitment of clAPs for the direct inhibition of caspase activation in the signaling complex. The stronger affinity and unique specificity of the TRADD-TRAF2 interaction are crucial for the suppression of apoptosis and provide a mechanistic basis for the perturbation of TRAF recruitment in sensitizing cell death induction.
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The line below this paragraph, {{ABSTRACT_PUBMED_10892748}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10892748 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10892748}}
==About this Structure==
==About this Structure==
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[[Category: Ye, H.]]
[[Category: Ye, H.]]
[[Category: A-b sandwich]]
[[Category: A-b sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:38:08 2008''

Revision as of 23:38, 30 June 2008

Image:1f3v.png

Template:STRUCTURE 1f3v

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE N-TERMINAL DOMAIN OF TRADD AND THE TRAF DOMAIN OF TRAF2

Template:ABSTRACT PUBMED 10892748

About this Structure

1F3V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction., Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H, Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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