This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




1f45

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1f45.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1f45.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1f45| PDB=1f45 | SCENE= }}
{{STRUCTURE_1f45| PDB=1f45 | SCENE= }}
-
'''HUMAN INTERLEUKIN-12'''
+
===HUMAN INTERLEUKIN-12===
-
==Overview==
+
<!--
-
Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10899108}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10899108 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10899108}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Interleukin]]
[[Category: Interleukin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:52:29 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:39:11 2008''

Revision as of 23:39, 30 June 2008

Image:1f45.png

Template:STRUCTURE 1f45

HUMAN INTERLEUKIN-12

Template:ABSTRACT PUBMED 10899108

About this Structure

1F45 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108

Page seeded by OCA on Tue Jul 1 02:39:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f45"
Personal tools