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| | ==ApoL1 N-terminal domain== | | ==ApoL1 N-terminal domain== |
| - | <StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='7l6k' size='340' side='right'caption='[[7l6k]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[7l6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7l6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6K FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APOL1, APOL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6k OCA], [https://pdbe.org/7l6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6k RCSB], [https://www.ebi.ac.uk/pdbsum/7l6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6k ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Disease == | | == Disease == |
| - | [[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.
| + | [https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry. |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN]] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
| + | [https://www.uniprot.org/uniprot/APOL1_HUMAN APOL1_HUMAN] May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Fairbrother, W J]] | + | [[Category: Fairbrother WJ]] |
| - | [[Category: Holliday, M J]] | + | [[Category: Holliday MJ]] |
| - | [[Category: Kirchhofer, D]] | + | [[Category: Kirchhofer D]] |
| - | [[Category: Moran, P]] | + | [[Category: Moran P]] |
| - | [[Category: Ultsch, M]] | + | [[Category: Ultsch M]] |
| - | [[Category: Ion channel]]
| + | |
| - | [[Category: Kidney disease]]
| + | |
| - | [[Category: Lipoprotein]]
| + | |
| - | [[Category: Membrane protein]]
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| Structural highlights
Disease
APOL1_HUMAN Genetic steroid-resistant nephrotic syndrome. The disease is caused by variants affecting the gene represented in this entry.
Function
APOL1_HUMAN May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
Publication Abstract from PubMed
Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly increased risk of chronic kidney disease. Here we present X-ray and NMR structures of the N-terminal domain (NTD) of ApoL1 and of its closest relative ApoL2. In both proteins, four of the five NTD helices form a four-helix core structure which is different from the classical four-helix bundle and from the pore-forming domain of colicin A. The reactivity with a conformation-specific antibody and structural models predict that this four-helix motif is also present in the NTDs of ApoL3 and ApoL4, suggesting related functions within the small ApoL family. The long helix 5 of ApoL1 is conformationally flexible and contains the BH3-like region. This BH3-like alpha-helix resembles true BH3 domains only in sequence and structure but not in function, since it does not bind to the pro-survival members of the Bcl-2 family, suggesting a Bcl-2-independent role in cytotoxicity. These findings should expedite a more comprehensive structural and functional understanding of the ApoL immune protein family.
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif.,Ultsch M, Holliday MJ, Gerhardy S, Moran P, Scales SJ, Gupta N, Oltrabella F, Chiu C, Fairbrother W, Eigenbrot C, Kirchhofer D Commun Biol. 2021 Jul 27;4(1):916. doi: 10.1038/s42003-021-02387-5. PMID:34316015[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ultsch M, Holliday MJ, Gerhardy S, Moran P, Scales SJ, Gupta N, Oltrabella F, Chiu C, Fairbrother W, Eigenbrot C, Kirchhofer D. Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol. 2021 Jul 27;4(1):916. doi: 10.1038/s42003-021-02387-5. PMID:34316015 doi:http://dx.doi.org/10.1038/s42003-021-02387-5
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