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1n4n
From Proteopedia
(Difference between revisions)
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==Structure of the Plant Defensin PhD1 from Petunia Hybrida== | ==Structure of the Plant Defensin PhD1 from Petunia Hybrida== | ||
| - | <StructureSection load='1n4n' size='340' side='right'caption='[[1n4n | + | <StructureSection load='1n4n' size='340' side='right'caption='[[1n4n]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1n4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Petunia_x_hybrida Petunia x hybrida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4N FirstGlance]. <br> | <table><tr><td colspan='2'>[[1n4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Petunia_x_hybrida Petunia x hybrida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N4N FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4n OCA], [https://pdbe.org/1n4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4n RCSB], [https://www.ebi.ac.uk/pdbsum/1n4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4n ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4n OCA], [https://pdbe.org/1n4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n4n RCSB], [https://www.ebi.ac.uk/pdbsum/1n4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n4n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DEF1_PETHY DEF1_PETHY] Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4n ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n4n ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The structure of a novel plant defensin isolated from the flowers of Petunia hybrida has been determined by (1)H NMR spectroscopy. P. hybrida defensin 1 (PhD1) is a basic, cysteine-rich, antifungal protein of 47 residues and is the first example of a new subclass of plant defensins with five disulfide bonds whose structure has been determined. PhD1 has the fold of the cysteine-stabilized alphabeta motif, consisting of an alpha-helix and a triple-stranded antiparallel beta-sheet, except that it contains a fifth disulfide bond from the first loop to the alpha-helix. The additional disulfide bond is accommodated in PhD1 without any alteration of its tertiary structure with respect to other plant defensins. Comparison of its structure with those of classic, four-disulfide defensins has allowed us to identify a previously unrecognized hydrogen bond network that is integral to structure stabilization in the family. | ||
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| - | Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds.,Janssen BJ, Schirra HJ, Lay FT, Anderson MA, Craik DJ Biochemistry. 2003 Jul 15;42(27):8214-22. PMID:12846570<ref>PMID:12846570</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1n4n" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Plant defensin|Plant defensin]] | *[[Plant defensin|Plant defensin]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Petunia x hybrida]] | [[Category: Petunia x hybrida]] | ||
| - | [[Category: Anderson | + | [[Category: Anderson MA]] |
| - | [[Category: Craik | + | [[Category: Craik DJ]] |
| - | [[Category: Janssen | + | [[Category: Janssen BJC]] |
| - | [[Category: Lay | + | [[Category: Lay FT]] |
| - | [[Category: Schirra | + | [[Category: Schirra HJ]] |
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Current revision
Structure of the Plant Defensin PhD1 from Petunia Hybrida
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