1nm7
From Proteopedia
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==Solution structure of the ScPex13p SH3 domain== | ==Solution structure of the ScPex13p SH3 domain== | ||
| - | <StructureSection load='1nm7' size='340' side='right'caption='[[1nm7 | + | <StructureSection load='1nm7' size='340' side='right'caption='[[1nm7]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1nm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1nm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NM7 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nm7 OCA], [https://pdbe.org/1nm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1nm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nm7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nm7 OCA], [https://pdbe.org/1nm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1nm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nm7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PEX13_YEAST PEX13_YEAST] Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nm7 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nm7 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Pex13p is an essential component of the peroxisomal protein import machinery and interacts via its C-terminal SH3 domain with the type II SH3-ligand Pex14p and the non-PXXP protein Pex5p. We report the solution structure of the SH3 domain of Pex13p from Saccharomyces cerevisiae and the identification of a novel-binding pocket, which binds a non-PXXP-peptide representing the binding site of Pex5p. Chemical shift assays revealed the binding sites for Pex5p and Pex14p ligand peptides to be distinct and spatially separated. Competition assays demonstrated that the two ligand peptides can bind simultaneously to the SH3 domain. | ||
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| - | The ScPex13p SH3 domain exposes two distinct binding sites for Pex5p and Pex14p.,Pires JR, Hong X, Brockmann C, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H, Erdmann R J Mol Biol. 2003 Mar 7;326(5):1427-35. PMID:12595255<ref>PMID:12595255</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1nm7" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 18824]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brockmann | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: Erdmann | + | [[Category: Brockmann C]] |
| - | [[Category: Hong | + | [[Category: Erdmann R]] |
| - | [[Category: Oschkinat | + | [[Category: Hong X]] |
| - | [[Category: Pires | + | [[Category: Oschkinat H]] |
| - | [[Category: Schneider-Mergener | + | [[Category: Pires JR]] |
| - | [[Category: Volkmer-Engert | + | [[Category: Schneider-Mergener J]] |
| - | + | [[Category: Volkmer-Engert R]] | |
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Revision as of 08:51, 10 April 2024
Solution structure of the ScPex13p SH3 domain
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