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1oda

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Current revision (12:36, 13 December 2023) (edit) (undo)
 
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<StructureSection load='1oda' size='340' side='right'caption='[[1oda]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
<StructureSection load='1oda' size='340' side='right'caption='[[1oda]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1oda]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ODA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1oda]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ODA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDU:ME-A-9-N-(BIPHENYL-4-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>BDU</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.31&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1od7|1od7]], [[1od9|1od9]], [[1qfo|1qfo]], [[1qfp|1qfp]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDU:ME-A-9-N-(BIPHENYL-4-CARBONYL)-AMINO-9-DEOXY-NEU5AC'>BDU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oda OCA], [https://pdbe.org/1oda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oda RCSB], [https://www.ebi.ac.uk/pdbsum/1oda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oda ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oda OCA], [https://pdbe.org/1oda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oda RCSB], [https://www.ebi.ac.uk/pdbsum/1oda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oda ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE]] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
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[https://www.uniprot.org/uniprot/SN_MOUSE SN_MOUSE] Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.<ref>PMID:15364954</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Brossmer, R]]
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[[Category: Brossmer R]]
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[[Category: Crocker, P R]]
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[[Category: Crocker PR]]
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[[Category: Jones, E Y]]
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[[Category: Jones EY]]
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[[Category: Kelm, S]]
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[[Category: Kelm S]]
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[[Category: Maenaka, K]]
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[[Category: Maenaka K]]
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[[Category: Maenaka, T]]
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[[Category: Maenaka T]]
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[[Category: Zaccai, N R]]
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[[Category: Zaccai NR]]
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[[Category: Carbohydrate binding]]
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[[Category: Cell adhesion]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin superfamily]]
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[[Category: Inhibitor design]]
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[[Category: Lectin-immune system complex]]
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[[Category: Lectin/immune system]]
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[[Category: Siglec]]
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Current revision

N-terminal of Sialoadhesin in complex with Me-a-9-N-(biphenyl-4-carbonyl)-amino-9-deoxy-Neu5Ac (BIP compound)

PDB ID 1oda

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OCA

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