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1f4x

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[[Image:1f4x.gif|left|200px]]
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{{Seed}}
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[[Image:1f4x.png|left|200px]]
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{{STRUCTURE_1f4x| PDB=1f4x | SCENE= }}
{{STRUCTURE_1f4x| PDB=1f4x | SCENE= }}
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'''CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN'''
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===CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN===
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==Overview==
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The crystal structure of the murine Fab S-20-4 from a protective anti-cholera Ab specific for the lipopolysaccharide Ag of the Ogawa serotype has been determined in its unliganded form and in complex with synthetic fragments of the Ogawa O-specific polysaccharide (O-SP). The upstream terminal O-SP monosaccharide is shown to be the primary antigenic determinant. Additional perosamine residues protrude outwards from the Ab surface and contribute only marginally to the binding affinity and specificity. A complementary water-excluding hydrophobic interface and five Ab-Ag hydrogen bonds are crucial for carbohydrate recognition. The structure reported here explains the serotype specificity of anti-Ogawa Abs and provides a rational basis toward the development of a synthetic carbohydrate-based anti-cholera vaccine.
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The line below this paragraph, {{ABSTRACT_PUBMED_10880560}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10880560 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10880560}}
==About this Structure==
==About this Structure==
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[[Category: Souchon, H.]]
[[Category: Souchon, H.]]
[[Category: Anti-carbohydrate antibody]]
[[Category: Anti-carbohydrate antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:54:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:41:55 2008''

Revision as of 23:41, 30 June 2008

Image:1f4x.png

Template:STRUCTURE 1f4x

CRYSTAL STRUCTURE OF AN ANTI-CARBOHYDRATE ANTIBODY DIRECTED AGAINST VIBRIO CHOLERAE O1 IN COMPLEX WITH ANTIGEN

Template:ABSTRACT PUBMED 10880560

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity., Villeneuve S, Souchon H, Riottot MM, Mazie JC, Lei P, Glaudemans CP, Kovac P, Fournier JM, Alzari PM, Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8433-8. PMID:10880560

Page seeded by OCA on Tue Jul 1 02:41:55 2008

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