1f59

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[[Image:1f59.gif|left|200px]]
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{{Seed}}
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[[Image:1f59.png|left|200px]]
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{{STRUCTURE_1f59| PDB=1f59 | SCENE= }}
{{STRUCTURE_1f59| PDB=1f59 | SCENE= }}
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'''IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX'''
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===IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX===
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==Overview==
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We describe the crystal structure of a complex between importin-beta residues 1-442 (Ib442) and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex face of Ib442 to a primary site between the A helices of HEAT repeats 5 and 6, and to a secondary site between HEAT repeats 6 and 7. Mutations at importin-beta Ile178 in the primary FxFG binding site reduce both binding and nuclear protein import, providing direct evidence for the functional significance of the importin-beta-FxFG interaction. The FxFG binding sites on importin-beta do not overlap with the RanGTP binding site. Instead, RanGTP may release importin-beta from FxFG nucleoporins by generating a conformational change that alters the structure of the FxFG binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_10929717}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10929717 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10929717}}
==About this Structure==
==About this Structure==
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[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:55:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:43:17 2008''

Revision as of 23:43, 30 June 2008

Image:1f59.png

Template:STRUCTURE 1f59

IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX

Template:ABSTRACT PUBMED 10929717

About this Structure

1F59 is a Single protein structure of sequence from Homo sapiens and Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking., Bayliss R, Littlewood T, Stewart M, Cell. 2000 Jul 7;102(1):99-108. PMID:10929717

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