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1f5q

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[[Image:1f5q.gif|left|200px]]
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{{STRUCTURE_1f5q| PDB=1f5q | SCENE= }}
{{STRUCTURE_1f5q| PDB=1f5q | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2'''
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===CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2===
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==Overview==
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Several gamma-herpesviruses encode proteins related to the mammalian cyclins, regulatory subunits of cyclin-dependent kinases (cdks) essential for cell cycle progression. We report a 2.5 A crystal structure of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2. The viral cyclin binds cdk2 with an orientation different from cyclin A and makes several novel interactions at the interface, yet it activates cdk2 by triggering conformational changes similar to cyclin A. Sequences within the viral cyclin N-terminus lock part of the cdk2 T-loop within the core of the complex. These sequences and others are conserved amongst the viral and cellular D-type cyclins, suggesting that this structure has wider implications for other cyclin-cdk complexes. The observed resistance of this viral cyclin-cdk complex to inhibition by the p27(KIP:) cdk inhibitor is explained by sequence and conformational variation in the cyclin rendering the p27(KIP:)-binding site on the cyclin subunit non-functional.
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(as it appears on PubMed at http://www.pubmed.gov), where 10856233 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10856233}}
==About this Structure==
==About this Structure==
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[[Category: Cyclin dependent kinase. protein/protein complex]]
[[Category: Cyclin dependent kinase. protein/protein complex]]
[[Category: Herpesviral cyclin]]
[[Category: Herpesviral cyclin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:56:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:44:29 2008''

Revision as of 23:44, 30 June 2008

Image:1f5q.png

Template:STRUCTURE 1f5q

CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2

Template:ABSTRACT PUBMED 10856233

About this Structure

1F5Q is a Protein complex structure of sequences from Homo sapiens and Murid herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Crystal structure of a gamma-herpesvirus cyclin-cdk complex., Card GL, Knowles P, Laman H, Jones N, McDonald NQ, EMBO J. 2000 Jun 15;19(12):2877-88. PMID:10856233

Page seeded by OCA on Tue Jul 1 02:44:29 2008

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