1buy
From Proteopedia
(New page: 200px<br /> <applet load="1buy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1buy" /> '''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE...) |
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'''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''<br /> | '''HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The solution structure of human erythropoietin (EPO) has been determined | + | The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BUY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1BUY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BUY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Aoki, K | + | [[Category: Aoki, K H.]] |
| - | [[Category: Cheetham, J | + | [[Category: Cheetham, J C.]] |
[[Category: Egrie, J.]] | [[Category: Egrie, J.]] | ||
| - | [[Category: Harvey, T | + | [[Category: Harvey, T S.]] |
| - | [[Category: Hoeffel, T | + | [[Category: Hoeffel, T J.]] |
| - | [[Category: Smith, D | + | [[Category: Smith, D M.]] |
| - | [[Category: Stevenson, J | + | [[Category: Stevenson, J L.]] |
| - | [[Category: Syed, R | + | [[Category: Syed, R S.]] |
[[Category: cytokine]] | [[Category: cytokine]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: growth factor]] | [[Category: growth factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:23 2008'' |
Revision as of 09:59, 21 February 2008
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HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE
Contents |
Overview
The solution structure of human erythropoietin (EPO) has been determined by nuclear magnetic resonance spectroscopy and the overall topology of the protein is revealed as a novel combination of features taken from both the long-chain and short-chain families of hematopoietic growth factors. Using the structure and data from mutagenesis studies we have elucidated the key physiochemical properties defining each of the two receptor binding sites on the EPO protein. A comparison of the NMR structure of the free EPO ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
Disease
Known disease associated with this structure: Erythremia (1) OMIM:[133170]
About this Structure
1BUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743
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