1q5f

<StructureSection load='1q5f' size='340' side='right'caption='[[1q5f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1q5f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5F FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5f OCA], [https://pdbe.org/1q5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5f RCSB], [https://www.ebi.ac.uk/pdbsum/1q5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5f ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The structure of the N-terminal-truncated Type IVb structural pilin (t-PilS) from Salmonella typhi was determined by NMR. Although topologically similar to the recently determined x-ray structure of pilin from Vibrio cholerae toxin-coregulated pilus, the only Type IVb pilin with known structure, t-PilS contains many distinct structural features. The protein contains an extra pair of beta-strands in the N-terminal alphabeta loop that align with the major beta-strands to form a continuous 7-stranded antiparallel beta-sheet. The C-terminal disulfide-bonded region of t-PilS is only half the length of that of toxin-coregulated pilus pilin. A model of S. typhi pilus has been proposed and mutagenesis studies suggested that residues on both the alphabeta loop and the C-terminal disulfide-bonded region of PilS might be involved in binding specificity of the pilus. This model structure reveals an exposed surface between adjacent subunits of PilS that could be a potential binding site for the cystic fibrosis transmembrane conductance regulator.

NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus.,Xu XF, Tan YW, Lam L, Hackett J, Zhang M, Mok YK J Biol Chem. 2004 Jul 23;279(30):31599-605. Epub 2004 May 24. PMID:15159389<ref>PMID:15159389</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Hackett, J]]

[[Category: Mok, Y K]]

[[Category: Tan, Y W]]

[[Category: Xu, X F]]

[[Category: Zhang, M]]

[[Category: Type ivb pilin]]