1f7x

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[[Image:1f7x.gif|left|200px]]
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{{Seed}}
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[[Image:1f7x.png|left|200px]]
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{{STRUCTURE_1f7x| PDB=1f7x | SCENE= }}
{{STRUCTURE_1f7x| PDB=1f7x | SCENE= }}
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'''SOLUTION STRUCTURE OF C-TERMINAL DOMAIN ZIPA'''
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===SOLUTION STRUCTURE OF C-TERMINAL DOMAIN ZIPA===
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==Overview==
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ZipA, an essential component of cell division in Escherichia coli, interacts with the FtsZ protein at the midcell in one of the initial steps of septum formation. The high-resolution solution structure of the 144-residue C-terminal domain of E. coli ZipA (ZipA(185)(-)(328)) has been determined by multidimensional heteronuclear NMR. A total of 30 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of 2758 experimental NMR restraints. The atomic root means square distribution about the mean coordinate positions for residues 6-142 for the 30 structures is 0.37 +/- 0.04 A for the backbone atoms, 0. 78 +/- 0.05 A for all atoms, and 0.45 +/- 0.04 A for all atoms excluding disordered side chains. The NMR solution structure of ZipA(185)(-)(328) is composed of three alpha-helices and a beta-sheet consisting of six antiparallel beta-strands where the alpha-helices and the beta-sheet form surfaces directly opposite each other. A C-terminal peptide from FtsZ has been shown to bind ZipA(185)(-)(328) in a hydrophobic channel formed by the beta-sheet providing insight into the ZipA-FtsZ interaction. An unexpected similarity between the ZipA(185)(-)(328) fold and the split beta-alpha-beta fold observed in many RNA binding proteins may further our understanding of the critical ZipA-FtsZ interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 10924108 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10924108}}
==About this Structure==
==About this Structure==
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1F7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7X OCA].
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1F7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F7X OCA].
==Reference==
==Reference==
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[[Category: Septation]]
[[Category: Septation]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:50:33 2008''

Revision as of 23:50, 30 June 2008

Image:1f7x.png

Template:STRUCTURE 1f7x

SOLUTION STRUCTURE OF C-TERMINAL DOMAIN ZIPA

Template:ABSTRACT PUBMED 10924108

About this Structure

1F7X is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of ZipA, a crucial component of Escherichia coli cell division., Moy FJ, Glasfeld E, Mosyak L, Powers R, Biochemistry. 2000 Aug 8;39(31):9146-56. PMID:10924108

Page seeded by OCA on Tue Jul 1 02:50:33 2008

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