1f81

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{{STRUCTURE_1f81| PDB=1f81 | SCENE= }}
{{STRUCTURE_1f81| PDB=1f81 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP'''
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===SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP===
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==Overview==
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The TAZ2 (CH3) domain of the transcriptional adapter protein CBP has been implicated in direct functional interactions with numerous cellular transcription factors and viral oncoproteins. The solution structure of the TAZ2 domain of murine CBP has been determined by nuclear magnetic resonance (NMR). The protein adopts a novel helical fold stabilized by three zinc ions, each of which is bound to one histidine and three cysteine ligands in HCCC-type motifs. Each zinc-binding site is formed from the carboxy terminus of an alpha-helix, a short loop, and the amino terminus of the next alpha-helix. A peptide derived from the N-terminal transactivation domain of p53 binds specifically to one face of the TAZ2 domain. The close similarities between the TAZ2 and TAZ1 (CH1 domain of CBP/p300) sequences suggest that both domains will adopt similar three-dimensional structures.
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{{ABSTRACT_PUBMED_11023789}}
==About this Structure==
==About this Structure==
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1F81 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F81 OCA].
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1F81 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F81 OCA].
==Reference==
==Reference==
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[[Category: Taz2]]
[[Category: Taz2]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:50:49 2008''

Revision as of 23:50, 30 June 2008

Image:1f81.png

Template:STRUCTURE 1f81

SOLUTION STRUCTURE OF THE TAZ2 DOMAIN OF THE TRANSCRIPTIONAL ADAPTOR PROTEIN CBP

Template:ABSTRACT PUBMED 11023789

About this Structure

1F81 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of the TAZ2 (CH3) domain of the transcriptional adaptor protein CBP., De Guzman RN, Liu HY, Martinez-Yamout M, Dyson HJ, Wright PE, J Mol Biol. 2000 Oct 20;303(2):243-53. PMID:11023789

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