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1qou

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CEN (Centroradialis) protein from Antirrhinum

Structural highlights

1qou is a 2 chain structure with sequence from Antirrhinum majus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CEN_ANTMA Expression of CEN leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). May form complexes with phosphorylated ligands by interfering with kinases and their effectors.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Expression of the plant protein centroradialis (CEN) leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). We have determined the crystal structure of Antirrhinum CEN to 1.9 A resolution. This structure confirms the CEN proteins as a subset of the family of phosphatidylethanolamine-binding proteins (PEBP), as predicted from sequence homology. Mammalian forms of PEBP have been found to act as inhibitors of MAP kinase signalling, a central signalling cascade regulating cell differentiation. CEN and PEBP proteins share a similar topology dominated by a large central beta-sheet. The strong conservation of a binding pocket at one end of this sheet which is capable of binding phosphoryl ligands, suggests the biological effects of CEN, like PEBP, arise from the ability of this region to form complexes with phosphorylated ligands, hence interfering with kinases and their effectors.

The structure of Antirrhinum centroradialis protein (CEN) suggests a role as a kinase regulator.,Banfield MJ, Brady RL J Mol Biol. 2000 Apr 14;297(5):1159-70. PMID:10764580^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Banfield MJ, Brady RL. The structure of Antirrhinum centroradialis protein (CEN) suggests a role as a kinase regulator. J Mol Biol. 2000 Apr 14;297(5):1159-70. PMID:10764580 doi:10.1006/jmbi.2000.3619

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qou"

Categories: Antirrhinum majus | Large Structures | Banfield MJ | Brady RL

@@ Line 3: / Line 3: @@
 <StructureSection load='1qou' size='340' side='right'caption='[[1qou]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1qou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Antma Antma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1qou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Antirrhinum_majus Antirrhinum majus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QOU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qou OCA], [https://pdbe.org/1qou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qou RCSB], [https://www.ebi.ac.uk/pdbsum/1qou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qou ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qou OCA], [https://pdbe.org/1qou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qou RCSB], [https://www.ebi.ac.uk/pdbsum/1qou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qou ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CEN_ANTMA CEN_ANTMA]] Expression of CEN leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
+[https://www.uniprot.org/uniprot/CEN_ANTMA CEN_ANTMA] Expression of CEN leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). May form complexes with phosphorylated ligands by interfering with kinases and their effectors.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Antma]]
+[[Category: Antirrhinum majus]]
 [[Category: Large Structures]]
-[[Category: Banfield, M J]]
+[[Category: Banfield MJ]]
-[[Category: Brady, R L]]
+[[Category: Brady RL]]
-[[Category: Influorescence determination in flowering plant meristem]]
-[[Category: Member of the phosphatidylethanolamine binding protein family]]
-[[Category: Plant protein]]
-[[Category: Signalling]]

1qou

From Proteopedia

Current revision

CEN (Centroradialis) protein from Antirrhinum

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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