1qu3

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Current revision (05:57, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1qu3' size='340' side='right'caption='[[1qu3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='1qu3' size='340' side='right'caption='[[1qu3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1qu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QU3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1qu3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QU3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRC:MUPIROCIN'>MRC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isoleucine--tRNA_ligase Isoleucine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.5 6.1.1.5] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRC:MUPIROCIN'>MRC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu3 OCA], [https://pdbe.org/1qu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qu3 OCA], [https://pdbe.org/1qu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1qu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SYI1_STAAU SYI1_STAAU]] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).
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[https://www.uniprot.org/uniprot/SYI1_STAAU SYI1_STAAU] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Isoleucine--tRNA ligase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Silvian, L F]]
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[[Category: Staphylococcus aureus]]
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[[Category: Steitz, T A]]
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[[Category: Silvian LF]]
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[[Category: Wang, J]]
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[[Category: Steitz TA]]
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[[Category: Double-sieve]]
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[[Category: Wang J]]
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[[Category: Editing trna synthetase]]
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[[Category: Hydrolytic function]]
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[[Category: Ligase-rna complex]]
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[[Category: Metal ion]]
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[[Category: Shuttling mechanism]]
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Current revision

INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN

PDB ID 1qu3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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