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1f8z

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[[Image:1f8z.gif|left|200px]]
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{{Seed}}
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[[Image:1f8z.png|left|200px]]
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{{STRUCTURE_1f8z| PDB=1f8z | SCENE= }}
{{STRUCTURE_1f8z| PDB=1f8z | SCENE= }}
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'''NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR'''
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===NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR===
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==Overview==
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The sixth ligand-binding module of the low-density lipoprotein receptor contributes to the binding of apolipoprotein B100-containing lipoproteins. 1H NMR spectroscopy, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints. Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E-containing lipoproteins in addition to apolipoprotein B100-containing lipoproteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_10981718}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10981718 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10981718}}
==About this Structure==
==About this Structure==
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1F8Z is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].
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1F8Z is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].
==Reference==
==Reference==
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[[Category: Ldl receptor]]
[[Category: Ldl receptor]]
[[Category: Ligand-binding domain]]
[[Category: Ligand-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:02:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:53:18 2008''

Revision as of 23:53, 30 June 2008

Image:1f8z.png

Template:STRUCTURE 1f8z

NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR

Template:ABSTRACT PUBMED 10981718

About this Structure

1F8Z is a Single protein structure. Full experimental information is available from OCA.

Reference

Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities., Clayton D, Brereton IM, Kroon PA, Smith R, FEBS Lett. 2000 Aug 18;479(3):118-22. PMID:10981718

Page seeded by OCA on Tue Jul 1 02:53:18 2008

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