7dge
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==intermediate state of class C GPCR== |
| - | <StructureSection load='7dge' size='340' side='right'caption='[[7dge]]' scene=''> | + | <StructureSection load='7dge' size='340' side='right'caption='[[7dge]], [[Resolution|resolution]] 3.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7dge]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DGE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dge OCA], [https://pdbe.org/7dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dge RCSB], [https://www.ebi.ac.uk/pdbsum/7dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dge ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.65Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dge OCA], [https://pdbe.org/7dge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dge RCSB], [https://www.ebi.ac.uk/pdbsum/7dge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dge ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.<ref>PMID:7476890</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Hua T]] |
| + | [[Category: Liu ZJ]] | ||
| + | [[Category: Luo F]] | ||
| + | [[Category: Wu LJ]] | ||
| + | [[Category: Zhang JY]] | ||
Current revision
intermediate state of class C GPCR
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Categories: Homo sapiens | Lama glama | Large Structures | Hua T | Liu ZJ | Luo F | Wu LJ | Zhang JY
