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1f94

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{{STRUCTURE_1f94| PDB=1f94 | SCENE= }}
{{STRUCTURE_1f94| PDB=1f94 | SCENE= }}
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'''THE 0.97 RESOLUTION STRUCTURE OF BUCANDIN, A NOVEL TOXIN ISOLATED FROM THE MALAYAN KRAIT'''
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===THE 0.97 RESOLUTION STRUCTURE OF BUCANDIN, A NOVEL TOXIN ISOLATED FROM THE MALAYAN KRAIT===
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==Overview==
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Bucandin is a novel presynaptic neurotoxin isolated from Bungarus candidus (Malayan krait). It has the unique property of enhancing presynaptic acetylcholine release and represents a family of three-finger toxins with an additional disulfide in the first loop. There are no existing structures from this sub-category of three-finger toxins. The X-ray crystal structure of bucandin has been determined by the Shake-and-Bake direct-methods procedure. The resulting electron-density maps were of outstanding quality and allowed the automated tracing of 61 of the 63 amino-acid residues, including their side chains, and the placement of 48 solvent molecules. The 0.97 A resolution full-matrix least-squares refinement converged to a crystallographic R factor of 12.4% and the final model contains 118 solvent molecules. This is the highest resolution structure of any member of the three-finger toxin family and thus it can serve as the best model for other members of the family. Furthermore, the structure of this novel toxin will help in understanding its unique ability to enhance acetylcholine release. The unique structure resulting from the fifth disulfide bond residing in the first loop improves the understanding of other toxins with a similar arrangement of disulfide bonds.
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(as it appears on PubMed at http://www.pubmed.gov), where 11053837 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11053837}}
==About this Structure==
==About this Structure==
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[[Category: Uson, I.]]
[[Category: Uson, I.]]
[[Category: Three-finger snake presynaptic neurotoxin]]
[[Category: Three-finger snake presynaptic neurotoxin]]
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Revision as of 23:53, 30 June 2008

Image:1f94.png

Template:STRUCTURE 1f94

THE 0.97 RESOLUTION STRUCTURE OF BUCANDIN, A NOVEL TOXIN ISOLATED FROM THE MALAYAN KRAIT

Template:ABSTRACT PUBMED 11053837

About this Structure

1F94 is a Single protein structure of sequence from Bungarus candidus. Full crystallographic information is available from OCA.

Reference

The atomic resolution structure of bucandin, a novel toxin isolated from the Malayan krait, determined by direct methods., Kuhn P, Deacon AM, Comoso S, Rajaseger G, Kini RM, Uson I, Kolatkar PR, Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1401-7. PMID:11053837

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