7rb7
From Proteopedia
(Difference between revisions)
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==Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime== | ==Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime== | ||
| - | <StructureSection load='7rb7' size='340' side='right'caption='[[7rb7]]' scene=''> | + | <StructureSection load='7rb7' size='340' side='right'caption='[[7rb7]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RB7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RB7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rb7 OCA], [https://pdbe.org/7rb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rb7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rb7 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3VI:1,1-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}'>3VI</scene>, <scene name='pdbligand=NWA:4,4-DIHYDROXY-N,N,N-TRIMETHYLPENTAN-1-AMINIUM'>NWA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rb7 OCA], [https://pdbe.org/7rb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rb7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rb7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gerlits O]] | [[Category: Gerlits O]] | ||
[[Category: Kovalevsky A]] | [[Category: Kovalevsky A]] | ||
[[Category: Radic Z]] | [[Category: Radic Z]] | ||
Revision as of 16:28, 18 October 2023
Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime
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