1f97

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{{STRUCTURE_1f97| PDB=1f97 | SCENE= }}
{{STRUCTURE_1f97| PDB=1f97 | SCENE= }}
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'''SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE'''
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===SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE===
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==Overview==
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Junctional adhesion molecules (JAMs) are a family of immunoglobulin-like single-span transmembrane molecules that are expressed in endothelial cells, epithelial cells, leukocytes and myocardia. JAM has been suggested to contribute to the adhesive function of tight junctions and to regulate leukocyte trans migration. We describe the crystal structure of the recombinant extracellular part of mouse JAM (rsJAM) at 2.5 A resolution. rsJAM consists of two immunoglobulin-like domains that are connected by a conformationally restrained short linker. Two rsJAM molecules form a U-shaped dimer with highly complementary interactions between the N-terminal domains. Two salt bridges are formed in a complementary manner by a novel dimerization motif, R(V,I,L)E, which is essential for the formation of rsJAM dimers in solution and common to the known members of the JAM family. Based on the crystal packing and studies with mutant rsJAM, we propose a model for homophilic adhesion of JAM. In this model, U-shaped JAM dimers are oriented in cis on the cell surface and form a two-dimensional network by trans-interactions of their N-terminal domains with JAM dimers from an opposite cell surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 11500366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11500366}}
==About this Structure==
==About this Structure==
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[[Category: Beta-sandwich fold]]
[[Category: Beta-sandwich fold]]
[[Category: Immunoglobulin superfamily]]
[[Category: Immunoglobulin superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:03:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:54:00 2008''

Revision as of 23:54, 30 June 2008

Image:1f97.png

Template:STRUCTURE 1f97

SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE

Template:ABSTRACT PUBMED 11500366

About this Structure

1F97 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif., Kostrewa D, Brockhaus M, D'Arcy A, Dale GE, Nelboeck P, Schmid G, Mueller F, Bazzoni G, Dejana E, Bartfai T, Winkler FK, Hennig M, EMBO J. 2001 Aug 15;20(16):4391-8. PMID:11500366

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